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Under physiological conditions, most studies report no meaningful cross-reactivity among the peptide ligands and the receptors of this family [359,360]
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Madsen KS, Khler P, Khler LKA, Madsbad S, Gnesin F, Metzendorf MI, Richter B, Hemmingsen B
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10.1371/journal.pone.0058945 34
This highlights a gap in the research, as PsA has been less extensively studied with GLP-1RAs, and further studies are needed to confirm whether GLP-1RAs provide similar immunomodulatory and metabolic benefits in PsA as they do in PsO
