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In recent years, the cost of traditional drug development has increased significantly

PNPLA3 has hydrolase activity on triglycerides, and the I148M genetic variant is associated with a functional loss of this activity, which promotes the accumulation of triglycerides in hepatocytes and favors the development of hepatic steatosis 62

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Patients with established cardiovascular disease including previous myocardial infarction, stroke, or peripheral arterial diseaseare particularly suitable candidates, given the proven cardiovascular benefits of both drug classes

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