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Thus, although the increase in CNS-GLP-1R signaling is sufficient to activate BAT thermogenesis, whether this regulation is necessary for the contribution of BAT thermogenesis to the control of energy balance, or to the body weight lowering effects of GLP-1 based therapies still requires further investigation

Adding water spreads the same dose across more units

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[15] As an interesting side note, GLP-1 seems to do this at least partly by activating bitter taste receptors

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