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Duan D, Kim LJ, Jun JC, Polotsky VY

Jastreboff AM, Ryan DH, Bays HE, MariTide phase 2 obesity trial investigators et al (2025) Once-monthly maridebart cafraglutide for the treatment of obesity - a phase 2 trial

GNG4 is significantly upregulated in primary gastric cancer and liver metastasis

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Whilst attractive as a theory, it should, nevertheless, be borne in mind that the majority of the studies cited above have been carried out in rodents or have examined isolated islets/-cells under in vitro or ex vivo conditions, and whether a local pancreatic DPP-4/GLP-1 system plays an important role in normal human physiology or in the pharmacological effect of DPP-4 inhibitors is not clear

Also, combination cessation therapy may be needed in this special population