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In the DPP-4/Diprotin A co-crystal structure (PDB ID 1nu8), the peptide bond between the second and third residues is not cleaved after formation of the tetrahedral intermediate, wherein the sidechain of the catalytic serine (Ser630) is covalently linked to the carbonyl carbon atom Pro2

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Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, et al

Some may also include some sort of behavior-management coaching and other potential treatment options, like nutrition counseling and/or an exercise program

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