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Significance statement ![Figure][1] ### Competing Interest Statement The authors have declared no competing interest

Semaglutide can indirectly improve cellulite appearance through weight loss, but results depend on genetics, skin elasticity, and how quickly you lose fat

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The researchers analyzed data from a large, multi-institutional medical records database, including 73,483 adults taking GLP-1sincluding Semaglutide drugs like Ozempic & Wegovy, as well as Victoza (Liraglutide), Trulicity (Dulaglutide), or Byetta (Exenatide)and compared them with the same number of adults not taking the medications, tracking health outcomes for five years after treatment began

These hormones then communicate with the appetite-suppression pathway in the brain, reducing feelings of appetite, cravings, and caloric intake