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Enteroinsulin axis One of the main differences between GIP and GLP-1 is their influence on glucagon secretion: GLP-1 suppresses glucagon secretion, and GIP increases it, both in a glucose-dependent manner

[Cited 2022 January 21]

This should include hematocrit/hemoglobin and PSA (in appropriate age/risk groups)

However, in rare cases, it may indicate: Nutritional deficiencies (e.g., iron or B12) Undiagnosed hypothyroidism Low blood sugar levels , especially if youre skipping meals If youre concerned, always speak to a healthcare provider

Stay well hydrated, to promote healthy circulation

The observations in SUSTAIN-6 are predictable, given that intensified versus conventional insulin therapy is well known to have the capacity to precipitate initial worsening of retinopathy in patients with T2D with advanced preexisting retinopathy, as shown in the Diabetes Control and Complications Trial (82)