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Stigma has been widely reported as a major obstacle for initiation onto existing treatments for SUD and for transitioning long term pain patients from oxycodone to buprenorphine
We found that patients who underwent bariatric surgery experienced significantly greater weight loss in the year following treatment and had lower rates of weight gain compared to those on one of the GLP-1 medications, as seen in Figure 1

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137 These results bolster the notion that GLP-1 RAs could have an impact on cellular aging and potentially diminish age-related cellular aging in humans
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( F ) Quantification of exogenous palmitic acid oxidation measured in caSMCs that were pretreated with 100 nM GLP-1(2836) or scrambled control for 20 minutes
