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After the success of these first-generation GLP-1 medications in T2D, scientists continued to discover the wide-reaching effects and applications of this remarkable hormone

They have been shown to inhibit the expression of IFN-, IL-6, IL-1, and IL-2

There is also tremendous activity in the development of non peptidic small molecules targeting the incretin system to produce drugs that are orally available

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However, another study reported a significantly lower pathologic complete response rate among triple negative (ER-/PR-/HER2-) breast cancer patients taking GLP-1 agonists during neoadjuvant chemotherapy