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With oral GLP-1 formulations entering the market and a broader pipeline of next-generation agents on the horizon, benefit leaders now need a second layer of analysis: how today's trajectory informs spend projections as the product landscape expands

Notably, given that SGLT-2 is expressed in the brain, which is consistent located with enhanced cFos expression induced by SGLT-2is, we hypothesize that SGLT-2is may cross the BBB via receptor-mediated transcytosis

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(2023, April 28)

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