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Combining them is a clinical decision meant to address specific biological and psychological barriers that one drug alone might miss

More than half (55%) of the population was male

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When inflammation occurs, activation of neutrophils can release large amounts of NE, 61 causing damage to the lung parenchyma and alveolar wall, and increasing mucin synthesis and mucus secretion by promoting inflammatory cell aggregation and secretion of pro-mucin secretagogues, aggravating the airway inflammatory response and airway obstruction in COPD and causing a decrease in ventilation function