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This review aims to systematically summarise the current genetic factors associated with tirzepatide efficacy and toxicity, with a particular focus on variations in drug-metabolising enzymes, receptor targets, and signalling pathways

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When to seek medical attention : Contact your GP or diabetes team if your blood glucose consistently exceeds 15 mmol/L, if you develop symptoms of hyperglycaemia that persist for more than a few days, or if you experience any signs of diabetic complications

Limitations and Ongoing Research It's important to note that we don't fully understand why some patients don't seem to obtain the expected weight loss benefits from these medications

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