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Ozempic (generic: semaglutide) is a once-weekly injection medication for type-2 diabetes that was approved in 2017

First, observational studies evaluating drug effects inherently carry risks of confounding by indication and unmeasured confounding

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Other less common side effects can include pancreatitis, gastroparesis, bowel obstruction, gallstones, blockage of the bile duct and risk of acute kidney injury

Although diabetes is widely accepted as one of the major risk factors for cardiovascular disease, the cardiovascular safety of antidiabetic drugs has been questioned due to the finding that intensive glycemic control by antidiabetic medications may result in an unexpected increase in cardiovascular death under certain circumstances [6]

Patients with the following medical histories are typically advised against the use of these medications: Endocrine History: Individuals with a personal or family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)