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Despite their benefits, GLP-1 side effects can include gastrointestinal issues such as nausea, vomiting, diarrhea, and constipation

Coffee polyphenols have also been shown to increase postprandial release of active GLP-1 (view study)

Adverse Effects of GLP-1 Receptor Agonists PMC

A recent study reported that incretin therapy is not associated with an increased risk of pancreatic cancer in animals

This means that the root cause of PCOS (at least the majority of it) is insulin resistance, and this is why metformin is so commonly used to treat it

The GLP-1 companion-supplement market was valued at roughly $735 million in the US in 2025 and is projected to keep growing at a double-digit annual rate through the early 2030s