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Mounjaro (tirzepatide) works on both GLP-1 and GIP receptors and has shown greater average weight loss in trials (around 21% on the highest dose over 72 weeks compared with 15% for Wegovy 2.4 mg, or 21% on the new Wegovy 7.2 mg dose)

Monitoring requires baseline and ongoing liver function tests, FIB-4 scoring for fibrosis risk, and vigilance for pancreatitis and gallbladder disease

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There are protocol choices that significantly affect tolerability

Coverage can be more complicated when bupropion is prescribed for weight loss

Testosterone replacement increases lean muscle mass, bone mineral density, and basal metabolic rate through androgen receptor activation in target tissues