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a precise balance was achieved (Table 2)

Bias between mini-G s and -arrestin-2 recruitment was determined similarly to earlier work (Pickford et al ., 2020), by subtracting the log /K values (Kenakin et al ., 2012) for each ligand in each pathway for each assay to determine log /K A (referred to here as LogR)

BP lowering has not been consistently observed in two recent double-blind controlled clinical trials evaluating ambulatory BP as the primary end point
