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Even at 10 mg, weight loss averaged 19.5%

Semaglutide has been on the market longer, giving researchers more time to gather trial results, post-marketing data, and psychiatric studies

Paradoxically, despite greater potency, tirzepatide's GIP component may reduce nausea compared to semaglutide at equivalent effect levels

Network meta-analysis: an introduction for clinicians

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Both tirzepatide and semaglutide come with boxed warnings from the FDA (the strongest safety warning for prescription drugs) about the risk of developing thyroid C-cell tumors