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The highest dose of orforglipron helped patients lose on average 10.5% of their weight, or 22.9 pounds, on average at 72 weeks, compared to 2.2% weight loss among those who took a placebo

The results showed that tirzepatide was well-tolerated, with most participants experiencing mild to moderate adverse events such as nasopharyngitis, nausea, constipation, diarrhea, and decreased appetite

NAION is sometimes referred to as an eye stroke because it occurs when blood flow to the optic nerve becomes restricted, damaging the nerve fibers responsible for transmitting visual information to the brain