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In September 2023, an early publication of a meta-analysis study abstract also found that tirzepatide was more effective in reducing body weight than semaglutide which was recommended as a weight loss treatment for NHS use in England by the National Institute for Health and Care Excellence (NICE) in March 2023 at all respective doses

(Indeed, theres a principle that specifically opposes Occams razor in the context of medicineHickams dictum, which is typically presented as the observation that a patient can have as many diseases as they damn well please.) So although defaulting to the simplest explanation may make sense when all else is equal, biology is often far more complex than we predict, and therefore, we need to be ready to abandon or revise the simpler theory when presented with new information

Without censoring the participants after they started symptomatic therapy (Fig

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