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If you were taking semaglutide before switching to tirzepatide , the contraceptive interference risk increased when you made that switch

The middle third of the anterior and lateral thigh provides the safest zone with the most consistent subcutaneous tissue depth

And your baseline tolerance is more predictable

Key secondary objectives will be to demonstrate the superiority of tirzepatide 5 mg and/or MTD compared to placebo in: (1) maintaining 80% of the body weight reduction achieved during the 60week weightloss period and (2) maintaining 15% body weight reduction for participants who have already lost 15% body weight at randomization (Week 60) including only participants who reached the body weight plateau by the end of the weightloss period (Week 60)

Some common side effects include nausea, vomiting, diarrhea, and constipation, especially when starting or increasing the dose

The most common gastrointestinal symptoms include: Nausea (1220% of patients): Usually mild to moderate, most pronounced 13 days after injection, typically improving within the first month Diarrhea (716% of patients): Often resolves as the body adjusts to the medication Decreased appetite : An expected pharmacologic effect that contributes to weight loss Constipation (57% of patients): May require dietary fiber adjustments or stool softeners Vomiting (28% of patients): Less common but warrants medical attention if persistent Abdominal discomfort or bloating : Related to delayed gastric emptying Most gastrointestinal side effects are mild to moderate in severity and diminish significantly after 48 weeks as tolerance develops