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Tissue perfusion and sexual function pathways A case report of female anorgasmia and hypoarousal temporally related to GLP-1 agonist use (including semaglutide after a switch from liraglutide) proposed mechanisms including smooth-muscle vasoconstriction with reduced genital blood flow and central neurotransmitter pathway effects (hypothalamic signalling)

Many GLP-1 users drift into dangerously low calorie intake simply because they are not hungry, not because they are deliberately restricting

Do not increase the dose early, even if you feel fine

For a comprehensive look at this topic, our guide on GLP-1 and hair loss covers prevention strategies, supplementation protocols, and when to seek dermatological evaluation

Planning ahead for each dose increase can help minimize symptoms
