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Structured exercise, adequate sleep, and targeted use of probiotics and selected nutraceuticals provide additional, evidence-informed levers to complement pharmacological GLP-1RAs or to support metabolic health in individuals who are not using these medications

More details about TTO analysis and classification of can be found in the Additional file 1, sections 45

Such evidence has been corroborated by trials showing nephroprotective effects of SGLT2i in individuals with CKD of any origin, with or without type 2 diabetes [8, 9]

Manufacturers claim these adhesive patches gradually release active ingredients through the skin to support weight loss over time and control appetite

After the 56-week treatment period, BMI standard deviation scores (BMI SDS) decreased by a mean of 0.23 in the liraglutide group, with no change in the placebo group

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