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190 In general, cyanopyrrolidines such as saxagliptin are competitive inhibitors rather than noncompetitive inhibitors of DPP-IV enzymatic activity since they form reversible covalent bonds with serine residue 630 located within the enzyme's active site

However, she was readmitted just two days later with recurrence of symptoms and hypoglycaemia with blood sugar at 3.5 mmol/l

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Patients with specific genetic profiles may achieve excellent results at 0.75mg, while others with different variants might respond better to dose advancement