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SGLT-2 accounts for the majority of glucose reabsorption in the kidney and has, thus, surfaced as a therapeutic target for the treatment of T2DM

Secondary and sensitivity analyses In our secondary analyses, we did not observe evidence of effect measure modification by individual drug, age, sex, body mass index, history of suicidal ideation, history of depression, or socioeconomic status, as indicated by overlapping 95% confidence intervals in all comparisons (supplementary tables S4-S7)

In clinical trials, injection site reactions were common in people taking Saxenda

Common reported side effects include nausea, vomiting, constipation, diarrhea, reduced appetite, and unusual skin sensations

We observed no diarrhea after acute administration of liraglutide

Some patients do not respond well to semaglutide or tirzepatide, or experience side effects with weekly injectables that they do not experience with liraglutide