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Retatrutide is currently an investigational agent not yet FDA-approved for clinical use

Weight-loss pens have been available on the pharmaceutical market for about a decade, initially appearing internationally

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Future randomised controlled trials should specifically evaluate the effectiveness of novel AOMs for long-term weight management in older adults with obesity, carefully considering the impact on body composition and functional ability, as well as health economics.

It works by increasing insulin production and lowering glucagon secretion, as well as targets areas in the brain that regulate appetite and food intake.