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Hypocaloric diets, when not adjusted for protein density, increase the risk of disproportionate lean mass loss [41]

F., Lima, F

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Allosteric (off active site) activators were reported in the literature as early as the mid-2000s, but they had poor potency, poor pharmacokinetics, species-selective activity (human but not rodent), and none made it close to the clinic

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Importantly, OXM treatment led to several beneficial metabolic effects not seen in OXMQ3E treated mice including a decrease in plasma triglycerides and plasma cholesterol in addition to an increase in adiponectin
