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Because providers understand the absorption limitations, many prescribe significantly higher daily doses of oral tirzepatide compared to the weekly injectable dose

this is called pulmonary aspiration and can be life-threatening

Efficacy and safety of tirzepatide, GLP-1 receptor agonists, and other weight loss drugs in overweight and obesity: a network meta-analysis

Some dose escalation protocols extend the 2.5 mg phase to 6 or even 8 weeks if side effects were significant during the initial month

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