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As anticipated, the low-calorie diet led to an increase in CTX (+ 27%) and PINP (+ 7%), indicating increased bone turnover favoring bone resorption [74] ( Fig

The cohort included 111 patients (median age at GLP-1RA initiation, 15 years

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Emerging imaging studies suggest tirzepatide may improve muscle quality , reducing fat infiltration within muscle tissue even as overall lean mass decreasesindicating a potential improvement in muscle composition rather than functional loss