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Effects of Incretin Pathway Elements on Bone Properties
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By testing a theoretical range of human GLP-1R potencies at a once-weekly 50 mg dose and assuming the peptide retains its activity over the dosing period, simulations showed that a potency 40-fold less than the reference GLP-1-Fc(4) molecule should deliver equivalent GLP-1 activity to a 1.5 mg weekly dose of GLP-1-Fc(4) (Supplementary Fig
Injectable therapy can cause vomiting and is inconvenient [232]
More data is not always better
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