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Also worth noting these are relative risk reductions

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The excessive proliferation of VSMCs could accelerate the deposition of atherosclerotic plaques in the vascular intima, leading to intimal thickening and vascular remodeling [102, 103]

Our physicians provide practical guidance for managing these effects, and the majority of patients find they diminish substantially after the first few weeks at each dose level

That's the strongest argument for using the quiet window deliberately

But back then, we didnt have as much data as we do now