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Description
Among the subcutaneous GLP-1 receptor agonists, some are dosed once daily (liraglutide and lixisenatide) or twice daily (exenatide), whereas others are given once weekly (dulaglutide, semaglutide, and exenatide extended release) (813)

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Insulin secretion-independent effects of GLP-1 on canine liver glucose metabolism do not involve portal vein GLP-1 receptors

Those are decent numbers

If you experience intolerable side effects with standard doses, customized microdoses of compounded semaglutide may help achieve desired results with minimal side effects
Instructing the patient to administer the evening NPH insulin dose at bedtime rather than before dinner helps prevent insulin waning and ensures better glycemic control upon waking
