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doi: 10.1016/S0140-6736(18)30726-8 84 ParkerVERRobertsonDWangTHornigoldDCPetroneMCooperATet al

Conclusions: The improvement in symptoms and clinical signs of lipedema, in addition to the reduction in adipose tissue in patients with lipedema and insulin resistance with exenatide, suggests a novel pharmacological approach to the disease, which can be combined with other conservative and surgical treatments to promote weight reduction

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Dihydroberberine (DHB) is much more bioavailable than ordinary berberine and achieves similar effects at vastly smaller doses

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