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One such study by McClean and colleagues [61] observed that liraglutide can cross the blood-brain barrier in substantial amounts and can prevent deficits in the water maze task performance and object recognition in AD model mice

The decrease in BMI from these drugs will likely lead to a lower risk of obesity-associated cancers, including breast, colorectal, and endometrial cancer

Author Contributions H.A wrote main manuscript text, and created Tables 1 and 2

Clinical trial data from the STEP program showed that semaglutide 2.4mg weekly produced average weight loss of 14.9% of body weight over 68 weeks, compared to tirzepatide at 15mg which achieved approximately 22.5% in the SURMOUNT trials

A 2024 clinical study examined participants supplementing with resistant starch and reported measurable reductions in body weight and visceral fat compared to placebo groups, without changes to diet or exercise