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NCT03914326) ( Pooled Analysis of SUSTAIN and PIONEER Trials Insights from the individual trials are complemented by a recent post-hoc patient-level analysis that combined data from the SUSTAIN 6 and PIONEER 6 trials, which was made possible by their similar designs ( post-hoc analyses, they suggest a potential for beneficial effects for semaglutide on CV outcomes regardless of the route of administration

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Indeed, the common hepatic branch, as well as celiac and gastric branches, have all been implicated in contributing to the glucoregulatory effects of gut GLP-1 62,125,126 , although selective knockdown of GLP-1R in nodose ganglia does not impair oral glucose tolerance or glucose-stimulated insulin secretion, similar to genetic knockout of GLP-1R in vagal neurons 127,128