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Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node GLP-1 has direct chronotropic effects on the heart mediated by GLP-1 receptors in pacemaker cells of the sinus node, inducing changes in action potential morphology

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In clinical trials, people using GLP-1 drugs lost an average of about 10 pounds more than people using a placebo

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Pramlintide, Acetate [Pro25, 28, 29]-Amylin(1-37), Amide, analogue of human hormone Amylin

There is substantial evidence suggesting that AMPK is dysregulated in animals and humans with metabolic syndrome or T2D, and that AMPK activation (physiological or pharmacological) can improve insulin sensitivity and metabolic health