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Such studies should incorporate systematic assessment of total, bioavailable, and free testosterone levels, as well as estradiol, during pharmacologically induced weight loss in order to clarify whether normalization of the endocrine milieu mitigates lean mass decline

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Hormonal changes: GLP-1 receptor stimulation on ADSCs indirectly reduces estrogen production from dermal white adipose tissue (DWAT), which decreases fibroblast stimulation to produce collagen

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