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Description
Oral dosing also sidesteps needle aversion and simplifies distribution via traditional pharmacy channels
The region is becoming more accessible due to better medical infrastructure and the increasing adoption of GLP-1s in chronic disease programmes
Animal studies have shown some adverse effects at high doses, though relevance to humans remains uncertain
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Paracardiac adipose tissue (EAT and pericardial fat) decreased by 45 mL in the tirzepatide group ( p 30, is a significant contributor, with up to 80% of obese individuals developing MAFLD [37]

Clin Pharmacol (2022) 14:617
