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Gut hormone PYY3-36 physiologically inhibits food intake

Use of incretin mimetics as initial therapy for people with type 2 diabetes and obesity was not considered cost effective

34 Reduced Inflammation: Healthy muscle tissue may have anti-inflammatory properties, whereas excess fat tissue is linked to chronic inflammation

Therefore, phenotyping GLP-1R-expressing cells in the VTA and determining how GLP-1R activation alters activity of these neurons during cocaine seeking are essential next steps toward developing the next-generation of GLP-1R-based therapies to treat CUD

A more recent study published in 2025 aimed to establish whether bacterial cell extracts of VH muciniphila could stimulate insulin secretion in pancreatic beta cells and GLP-1 secretion in human L-cells the cells in the gut that are responsible for secreting digestive hormones, including GLP-1 and Peptide YY

Purchasing supplements from reputable sources and looking for third-party testing certifications can help mitigate these risks, though it does not eliminate them entirely