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Discussion We here show that a long-acting GLP-1RA inhibits the normally occurring increase in soluble leptin receptors during weight loss maintenance by 59% compared with a control group

These include glucose-dependent insulin secretion from pancreatic beta cells, suppression of inappropriately elevated glucagon secretion, delayed gastric emptying, and reduced appetite through central nervous system pathways

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The research also found that women with prepregnancy diabetes, a known risk factor for birth defects, were not more likely to take folic acid before pregnancy, highlighting a critical opportunity for prevention