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Current status: TRIUMPH-4 results available: December 2025 readout showing 28.7% weight loss at 68 weeks (Giblin et al., PMID 41090431) Additional TRIUMPH trials: Expected to report results through 2026, including TRIUMPH-Outcomes (cardiovascular endpoints, NCT06383390, completion Feb 2029) NDA submission timing: Eli Lilly must compile the full trial package before submitting

Starting at a low dose and increasing gradually helps minimize these effects

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Peptide-based therapeutics are inherently challenging to characterize due to their large molecular size and the potential for numerous impurities arising from synthesis, degradation, and formulation processes, Carrick said