new glp 1 medication FDA approves Foundayo, an oral GLP-1 alternative to Wegovy and Ozempic A Guide to GLP-1s: Resources

doi: 10.1007/s43440-021-00274-8

Despite Harvard Medical School research published in July 2024 showing diabetes patients prescribed semaglutide faced over four times higher NAION risk (and weight loss patients faced over seven times higher risk) Novo Nordisks current Ozempic and Wegovy labels still mention only generic vision changes without specifically identifying NAION or permanent blindness as known risks

Thus, increasing the activity of Sirtuin1 (SIRT1), an NAD + dependent deacetylase, can prevent HMGB1 from being released into extracellular space, thereby reducing the inflammatory response (100)

Clinical trials show that Ozempic leads to substantially greater weight reduction, while metformin typically results in more modest weight loss

If we assume that the weight reduction in adolescents associated with an improvement in MASLD is similar to the weight reduction associated with and improvement in MASLD in adults, then we could assume that this would translate to a 710 % decrease in percent of the 95th percentile of BMI

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