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The new class of weight-loss medications are hailed as game-changing wonder drugs, but just how safe and effective are they

The relative risk of symptomatic cholelithiasis was 1.6, 0.9, and 1.4 in liraglutide, dulaglutide, and semaglutide with number needed to harm of 3.14, 16.67, and 5.56, respectively

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In practice, this can be seen through prior authorization requirements that often request documentation of such comorbidities, reinforcing their role in determining patient eligibility and access

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