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Tirzepatide (GLP-1 + GIP): This is a newer, dual-action medication and the same active ingredient as Mounjaro and Zepbound

Contraindications include personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, severe pancreatitis, or active gallbladder disease

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Focusing only on pharmacy cost provides an incomplete and often misleading picture

But the drugs are extremely expensive, and many insurance companies do not cover the medications when patients use them to lose weight rather than to control diabetes

Interestingly, ERK activation has been described to occur both upstream and downstream of GLP-1 (29,48)