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doi: 10.1172/jci.insight.170419 [DOI] [PMC free article] [PubMed] [Google Scholar] 25

Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis

both exenatide and metformin had similar effects on microvascular endothelial function measured by the reactive hyperemic index (RHI), as well as levels of inflammatory and oxidative stress markers including C-reactive protein (CRP), oxidized LDL (oxLDL), and vascular cell adhesion molecule-1 (VCAM-1) levels [63]

For best results, use as part of a balanced diet and exercise program

However, both medications do not target glucagon (GCG) receptor (GCGR)

Recently Novo Nordisk announced the acquisition of INV-202, an oral CB1 inverse agonist designed to preferentially block CB1R in peripheral tissues