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It reports what investigators reported and does not draw independent conclusions, offer a meta-analysis, or extrapolate beyond the cited sources

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The durability of metabolic benefits after washout, the consequences of chronic pan-ERR activation in heart and kidney, and the potential for tolerance or compensatory network changes require longer studies

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Nausea affected up to about 29 percent of participants Diarrhea up to about 23 percent Vomiting up to about 13 percent in some studies Reports of sleep disturbance or insomnia were not prominent in the trial safety tables for Zepbound

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