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The market remained relatively static until 2021 when Novo Nordisks semaglutide (Ozempic for diabetes and Wegovy for obesity) was approved, showing nearly 10% weight loss over two years

12 Canonical GLP-1 receptor signaling involves coupling GLP-1R with Gs, a subtype of G subunit, but GLP-1R can also initiate diverse signaling patterns through non-Gs pathways

Vitamin D deserves separate mention because fat loss releases stored vitamin D from adipose tissue, temporarily increasing blood levels, but long-term reduced fat intake can lead to deficiency

The key message for microdosing: Semaglutide delivers benefits across doses
While these effects contribute to reduced food intake, they are not the primary mechanism of weight loss
