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The clinical significance of this is unknown, as only 7-day dosing has been tested in trials

These factors support continued research interest despite the disappointing oral efficacy results

Diabetes Care 45(Suppl 1):S816

For example, when looking at GLP-1 users who just started in the last 1-3 months, GLP-1 weight loss users spent 22% more (compared to the same 13-week period a year ago), while diabetes users spent slightly less

Whether investigating advanced metabolic protocols, comparing incretin efficacy, or exploring novel receptor polypharmacology, retatrutide offers a scientifically grounded avenue for inquiry that extends beyond the limits of currently approved therapies