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The beneficial effects of GLP-1RAs are best understood via their ability to mitigate pathophysiological mechanisms of diabetes, such as systemic inflammation, oxidative stress, endothelial dysfunction and vascular fibrosis, which are key contributors to cerebrovascular disease [38]

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There are currently no GLP-1 medications that can be absorbed through the skin

This affects how quickly food moves through the stomach, which can cause nausea or digestive discomfort

Semaglutide, the core of Ozempic, mimics a hormone to control blood sugar, aiding in managing type 2 diabetes

Dose titration of GLP-1 receptor agonists should follow manufacturer recommendations, typically starting at the lowest dose and increasing gradually every 4 weeks based on tolerability and glycaemic response