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Nearly all of the discomfort people report clusters into the first one to two weeks after each dose increase, then fades as your body adapts
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These benefits were subsequently confirmed in well-powered studies specifically designed to evaluate kidney outcomes [1, 2]
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This effect appears to involve modulation of reward pathways and satiety signaling, leading to decreased caloric consumption
Meaning, once you lose the weight, you should continue taking your therapeutic dose for the rest of your life
