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Pharmacological medicines (topiramate and lisdexamfetamine) that are currently approved for these eating disorders are associated with adverse side effects, such as headache, paresthesia, sedation, and increased heart rate and blood pressure

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Spironolactone directly increases potassium retention by preventing its excretion in urine, while GLP-1 medications may indirectly affect renal potassium handling through changes in kidney perfusion and blood pressure

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In contrast, SCFAs (such as butyrate) tend to promote ferroptosis and suppress tumor growth by downregulating SLC7A11 and GPX4 expression

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